Police believe the three were killed in a gang-related shooting.
According to police, a man, his brother and his two children came under fire while they were seated inside their car outside a scrap metal yard on the corner of Mazeppa and Pickering streets in Point.
Netcare’s Shawn Herbst says the two men died on the scene while the children, a girl aged 17 and a boy aged 12, were seriously injured.
“The minor female had sustained critical injuries and was rushed to hospital. The minor male had sustained serious injuries and was stabilised on scene before being transported to hospital for further care.